Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfactant. It exhibits toxicity and anticancer effects, inhibiting cell migration and invasion by modulating canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide is also utilized for DNA extraction.
- Cationic surfactant.
- Exhibits toxicity and anticancer effects.
- Inhibits cell migration and invasion by modulating TGF-β signaling pathways.
- Can be used for DNA extraction.
- Inhibits the protein expression of MMP-2 and MMP-9, and increases TIMP-1 and TIMP-2 protein expression in SK-HEP-1 cells.
- Induces apoptosis in human Head and neck cancer (HNC) cells.
- Ablated tumor-forming capacity of FaDu cells and delayed growth of established tumors in FaDu cells tumor-bearing mice.